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Stiff Person Syndrome (SPS): The 2026 Diagnostic Shift and the Push for Targeted Immunotherapy

"The medical landscape surrounding Stiff Person Syndrome (SPS) has reached a critical inflection point in September 2026, as clinicians pivot from long-term palliative care toward aggressive, mechanism-based interventions. Following years of high-profile public awareness, recent clinical data indicates a surge in earlier, more accurate diagnoses, though patients continue to face significant hurdles in accessing specialized neurologists capable of managing this rare autoimmune disorder. As research cohorts expand globally, the focus has shifted from managing muscle spasms to addressing the underlying neurological trigger: the loss of inhibitory..."

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