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The Human Microbiome and Dysbiosis in Clinical Disease: 2026 Diagnostic and Therapeutic Frontiers

"Clinical medicine in 2026 recognizes the human microbiome not merely as a passive collection of commensal organisms, but as a dynamic, metabolically active organ system integrated into human physiology. Comprising trillions of bacteria, fungi, archaea, and viruses residing primarily within the gastrointestinal tract, the microbiome orchestrates host metabolism, immune development, and neurological signaling. When this intricate ecosystem collapses—a state known as dysbiosis—the physiological consequences extend far beyond localized mucosal irritation, driving complex pathologies across multiple medical specialties. As sequencing technologies,..."

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